11/6/2019 · Results: In animals, acute and chronic administration of vortioxetine improves performance on objective measures that cover a broad range of cognitive domains. In human, vortioxetine appears to be a useful treatment option in MDD patients with cognitive dysfunction.
3/15/2018 · While improvements in mood were comparable for vortioxetine and paroxetine, numerical improvements in cognitive performance (DSST) were larger with vortioxetine. Vortioxetine significantly improved overall cognitive performance and clinician-rated functioning relative to placebo.
Conclusion: Vortioxetine constitutes a promising treatment for treatment of cognitive impairment in MDD, but its place in the therapeutic armamentarium still needs to be determined.
In this issue of the Journal, Lenze and colleagues examine the ability of the antidepressant vortioxetine to augment the cognitive effects of cognitive training in adults age 65 or older. Vortioxetine is a relatively new antidepressant with a unique pharmacological profile in that unlike most selective serotonin reuptake inhibitors (SSRIs …
A Focus on Vortioxetine – Mechanism of Action and Efficacy, A Focus on Vortioxetine – Mechanism of Action and Efficacy, Modes and nodes explain the mechanism of action of …
A Focus on Vortioxetine – Mechanism of Action and Efficacy, 6/11/2015 · Enhanced release of neurotransmitters may theoretically “tune” malfunctioning brain circuits. 6 – 11 Specifically, enhanced release of 5HT, NE, DA, ACh, and HA by vortioxetine could theoretically improve the efficiency of information processing in maladaptive brain circuits by facilitating long-term potentiation, synaptic plasticity, and enhanced pyramidal neuron activity leading to improvement not.
4/16/2015 · Vortioxetine May Have Specific Cognitive-Enhancing Effects in Depression. Peter Roy-Byrne, MD reviewing Mahableshwarkar AR et al. Neuropsychopharmacology 2015 Apr 1. Much of the improvement in cognition was not mediated by improvement in depressive symptoms.
